Advanced Glycation end Products, Oxidative Stress and Diabetic Nephropathy
نویسندگان
چکیده
منابع مشابه
Advanced glycation end products, oxidative stress and diabetic nephropathy
About 246 million people worldwide have diabetes in 2007. The global figure of people with diabetes is projected to increase to 370 million in 2030. As the prevalence of diabetes has risen to epidemic proportions worldwide, diabetic nephropathy has become one of the most challenging health problems. Therapeutic options such as strict blood glucose and blood pressure controls are effective for p...
متن کاملAdvanced glycation end products and diabetic nephropathy.
Chronic hyperglycemia and oxidative stress in diabetes results in the formation and accumulation advanced glycation end products (AGEs). AGEs have a wide range of chemical, cellular, and tissue effects that contribute to the development of microvascular complications. In particular, AGEs appear to have a key role in the diabetic nephropathy. Their importance as downstream mediators of tissue in...
متن کاملAdvanced glycation end-products in diabetic nephropathy
Throughout the industrialized (well-fed) Adverse effects of hyperglycaemia, once thought an epiphenomenon in the pathogenesis of diabetic microworld, diabetes mellitus is the most prevalent cause of end-stage renal disease (ESRD). Diabetic nephropathy and macrovascular complications, presently are a central focus of active clinical and basic investigation is as likely to develop in long-duratio...
متن کاملAdvanced Glycation End-Products and Their Receptor-Mediated Roles: Inflammation and Oxidative Stress
Glycation is a protein modification, which results in a change in a protein structure. Glycation is believed to be the etiology of various age-related diseases such as diabetes mellitus and Alz-heimer’s disease (AD). Activation of microglia and resident macrophages in the brain by glycated proteins with subsequent oxidative stress and cytokine release may be an important factor in the progressi...
متن کاملAdvanced Glycation End Products and Diabetic Complications
During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic complications like retinopathy, nephropathy, neuropathy, cardiomyopathy along with some other di...
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ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2010
ISSN: 1942-0900,1942-0994
DOI: 10.4161/oxim.3.2.11148